894 research outputs found

    Family Memoirs

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    Landscape with a Woman

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    Constitutional Revision--the Counties

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    Community Property

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    Covers cases on the surrender value of community insurance subject to inheritance tax and on distinguishing community and separate property

    Industrial Energy Conservation: In-Plant Recirculation of Cleaned Exhaust Air

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    The concept of recirculation as a means of energy conservation and reducing initial investment costs has received increased attention in the technical literature in recent years. This paper will demonstrate the energy savings potential for recirculation systems and will present industrial hygiene measurements to document the performance of an actual system operating in an industrial environment. Operating experience has shown that the dual goals of industrial hygiene and energy conservation are not easily achieved

    Alginate hydrogel has a negative impact on in vitro collagen 1 deposition by fibroblasts

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    Hydrogels have been widely investigated as 3D culture substrates because of their reported structural similarity to the extracellular matrix (ECM). Limited ECM deposition, however, occurs within these materials, so the resulting β€œtissues” bear little resemblance to those found in the body. Here matrix deposition by fibroblasts encapsulated within a calcium alginate (Ca-alg) hydrogel was investigated. Although the cells transcribed mRNA for coll IΞ± over a period of 3 weeks, very little collagen protein deposition was observed within the gel by histology or immunohistochemistry (IHC). Although molecular diffusion demonstrated charge dependency, this did not prevent the flux of both positively and negative charged amino acids through the gel, suggesting that the absence of ECM could not be attributed to substrate limitation. The flux of protein, however, was charge-dependent as proteins with a net negative charge passed quickly through the Ca-alg into the medium. The minimal collagen deposition within the Ca-alg was attributed to a combination of rapid movement of negatively charged procollagen through the gel and steric hindrance of fibril formation

    Introduction to \u3ci\u3eThe Pullman Strike and the Crisis of the 1890’s\u3c/i\u3e

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    The strike of Pullman carshop employees and the subsequent boycott that disrupted rail traffic throughout the territory west of Chicago in June-July 1894 marked the culmination of nearly two decades of the most severe and sustained labor conflict in American history. Yet until very recently little new scholarship has focused on the meaning of the Pullman strike and its historical context. By offering a close reading of contemporary perceptions of the strike and by examining the organizational and political continuities and discontinuities the Pullman conflict reveals, these essays resituate the strike in its historical context. They demonstrate that Pullman played an important role in defining the crisis of the 1890s, shaping a changing legal environment, spurring the development of a regulatory state, and fostering a new politics of progressive reform. On September 23-24, 1994, more than two hundred scholars, students, educators, labor activists, and interested members of the public gathered at Indiana State University in Terre Haute to reconsider the Pullman strike in the light of new historical scholarship in labor history. The conference featured public addresses by the historians David Montgomery and Nick Salvatore and Jack Scheinckman, the president of the Amalgamated Textile Workers\u27 Union (now UNITEβ€”the Union of Needle Trades, Industrial and Textile Employees). Scholars delivered thirty-six papers at thirteen sessions that focused on various dimensions of the strike and its meaning. This edited collection contains revised versions of key conference papers addressing the significance of the Pullman strike in its wider historical context

    Olanzapine and fluoxetine combination therapy for treatment-resistant depression: review of efficacy, safety, and study design issues

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    Treatment-resistant depression (TRD) is a common occurrence in clinical practice. Up to 30% of patients with major depression do not respond to conventional antidepressant treatment, while a significantly greater number of patients experience only partial symptom reduction. Numerous strategies may be applied by the practicing clinician to overcome limitations in the effectiveness of antidepressant monotherapy, including combining drug treatment with evidence-supported psychotherapies, combining antidepressants (combination pharmacotherapy), and combining antidepressants with other non-antidepressant psychotropic medications (augmentation treatment). One such augmentation strategy, the combination of the selective serotonin reuptake inhibitor, fluoxetine (FLX), with the atypical antipsychotic drug, olanzapine (OLZ), is supported by the results of four randomized, double-blind, acute phase studies of patients who had responded inadequately to antidepressant monotherapy. In each study, the FLX/OLZ combination caused rapid reduction in Montgomery-Asberg Depression Rating scale scores, with two of the four studies showing significantly greater improvement than antidepressant monotherapy at study endpoint. Effects of the FLX/OLZ combination were strongest in cases where failure to respond to two antidepressants prior to randomization was established during the current depressive episode. The FLX/OLZ combination was well-tolerated; however, body weight gain and increases in prolactin were greater than that of the antidepressant monotherapy groups, and were comparable to that of OLZ monotherapy. While effective during acute-phase treatment, questions remain regarding the long-term efficacy and safety of FLX/OLZ relative to antidepressant monotherapy and other combination strategies. Efforts aimed at determining the placement of FLX/OLZ among the available options for addressing TRD are limited by lack of comparison and sequential treatment studies. Important aspects of study design and directions for future research are discussed
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